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faculty & research
The faculty in Applied Medical Sciences have outstanding educational backgrounds and
extensive
experience as educators and as researchers.
To learn more about our faculty and their individual areas of active research, please click on the items to the right. Below are recent publications by faculty and a summary of the areas of research being pursued in the department.
Recent Publications
Brooks B , O'Brien TJ,
Ceryak S, Wise JP Sr, Wise SS, Wise JP Jr,
DeFabo E, Patierno SR.
Excision repair is required for genotoxin-induced
mutagenesis in mammalian cells.
Carcinogenesis, in press.
Wartenberg D, Thompson WD, Fitzgerald E, Gross HJ, Condon S, Kim N, Goun B, Opiekun R, and The UMDNJ Collaborative Project Working Group on Northeast US Ambient Air Quality and Adverse Birth Outcomes Surveillance. Developing integrated multi-state environmental public health surveillance. Journal of Public Health Management and Practice, in press.
Goodale BC, Walter R, Pelsue SC, Thompson WD, Wise SS, Winn RN, Mitani H, Wise JP Sr.
The cytotoxicity and genotoxicity of hexavalent
chromium in medaka (Oryzias latipes) cells. Aquatic Toxicology 2008; 87:60-67.
Wise JP Sr, Wise SS, Kraus S, Shaffiey F, Grau M, Chen TL, Perkins C, Thompson WD, Zheng T, Romano T, O'Hara T.
Hexavalent chromium is cytotoxic and genotoxic to the North Atlantic right
whale (Eubalaena glacialis) lung and testes fibroblasts. Mutation Research 2008; 650:30-38.
Xie H, Wise SS, Wise JP Sr. Deficient repair of particulate hexavalent chromium-induced DNA double
strand breaks leads to neoplastic transformation. Mutation Research 2008; 649:230-238.
Xie H, Holmes AL, Wise SS, Huang S, Peng C,
Wise JP Sr. Neoplastic transformation of human bronchial cells by lead chromate
particles. American Journal of Respiratory Cell
and Molecular Biology 2007; 37:544-552.
Stackpole MM, Wise SS, Grlickova-Duzevik E, Munroe RC, Thompson WD, Thacker J, Thompson LH, Hinz JM,
Wise JP Sr. Homologous recombination repair protects against particulate
chromate-induced chromosome instability in chinese hamster cells. Mutation Research 2007; 625:145-154.
McCloskey LA, Williams CM, Lichter E, Gerber M, Ganz ML, Sege R. Abused women disclose partner interference with health care: an unrecognized form of battering. Journal of General Internal Medicine 2007; 22:1067-1072.
Thompson WD, Wartenberg D. Additive versus multiplicative models in ecologic regression. Stochastic Environmental Research and Risk Assessment 2007; 21:635-646.
Lin SJ, Chang C, Ng AK, Wang SH, Li JJ, Hu CP.
Prevention of TGF-beta-induced apoptosis by interlukin-4 through Akt activation and p70S6K survival signaling pathways.
Apoptosis 2007; 12:1659-70.
Miceli-Libby L, Johnson MJ, Harrington A, Hara-Kaonga B, Ng AK, Liaw L.
Widespread delta-like-1 expression in normal adult mouse tissue and injured endothelium is reflected by expression of the Dll1 locus.
Journal of Vascular Research 2007; 45:1-9.
Rice DC, Reeve EA, Herlihy A, Zoeller RT, Thompson WD, Markowski VP.
Developmental delays and locomotor activity in the C57BL6/J mouse following neonatal exposure to the fully-brominated PBDE, decabromodiphenyl ether.
Neurotoxicology and Teratology 2007; 29:511-520.
Wise SS, Thompson WD, Aboueissa AM,
Mason MD, Wise, JP Sr.
Particulate depleted uranium is cytotoxic and clastogenic to human lung
cells.
Chemical Research in Toxicology 2007; 20:815-820.
Camrye E, Wise SS, Milligan P, Gordon N, Goodale B, Stackpole M, Patzlaff N, Aboueissa AM, Wise JP Sr.
Ku80 deficiency does not affect particulate chromate-induced chromosome damage and cytotoxicity in Chinese hamster ovary cells.
Toxicological Sciences 2007;97:348-354.
Zhang Y, Holford TR, Leaderer B, Boyle P, Zhu Y, Wang R, Zou K, Zhang B, Wise JP Sr, Qin Q, Kilfoy B, Han J, Zheng T.
Ultraviolet radiation exposure and risk of non-Hodgkin's lymphoma.
American Journal of Epidemiology 2007;165:1255-1264.
Savery LC, Grlickova-Duzevik E, Wise SS, Thompson WD, Hinz JM, Thompson LH, Wise JP Sr.
Role of the Fanc-g gene in protecting cells from particulate chromate-induced chromosome instability. Mutation Research 2007;626:120-127.
Chen D, Kennedy A, Wang JW, Zeng W, Zhao Q, Pearl M, Zhang M, Suo Z, Nesland JM, Qiao Y, Ng AK, Hirashima N, Yamane T, Mori Y, Mitsumata M, Ghersi G, Chen WT.
Activation of EDTA-resistant gelatinases in malignant human tumors. Cancer Research 2006;66:9977-85.
Wise SS, Holmes AL, Xie H, Thompson WD, Wise JP Sr.
Chronic exposure to particulate chromate induces spindle assembly checkpoint bypass in human lung sells.
Chemical Research in Toxicology 2006;19:1492-1498.
Wise SS, Holmes AL, Wise JP Sr.
Particulate and soluble hexavalent chromium are cytotoxic and genotoxic to human lung epithelial cells.
Mutation Research 2006;610:2-7.
Holmes AL, Wise SS, Sandwick SJ, Wise JP Sr.
The clastogenic effects of chronic exposure to particulate and soluble Cr(VI) in human lung cells.
Mutation Research 2006;610:8-13.
Grlickova-Duzevik E, Wise SS, Munroe RC, Thompson WD, Wise JP Sr.
XRCC1 protects cells from chromate-induced chromosome damage, but does not affect cytotoxicity.
Mutation Research 2006;610:31-37.
Holmes AL, Wise SS, Sandwick SJ, Lingle WL, Negron VC, Thompson WD, Wise JP Sr.
Chronic exposure to lead chromate causes centrosome abnormalities and aneuploidy in human lung cells.
Cancer Research 2006;66:4041-4048.
Grlickova-Duzevik E, Wise SS, Munroe RC, Thompson WD, Wise JP Sr.
XRCC1 protects against particulate chromate-induced chromosome damage and cytotoxicity in Chinese hamster ovary cells.
Toxicological Sciences 2006;92:409-415.
Godard CA, Wise SS, Kelly RS, Goodale B, Kraus S, Romano T, O'Hara T, Wise JP Sr.
Benzo[a]pyrene cytotoxicity in right whale (Eubalaena glacialis) skin, testis and lung cell lines.
Marine Environmental Research 2006;62:S20-S24.
Wise JP Sr, Goertz CEC, Wise SS, Morin AT, Dunn JL, Gulland FMD, Bozza M, Atkinson S, Thompson WD. Chromium cytotoxicity in steller sea lion lung, skin and testes sells. In Trites AW, Atkinson SK, DeMaster DP, Fritz LW, Gelatt TS, Rea LD, Wynne KM (Eds), Sea Lions of the World: Conservation and Research in the 21st Century. Alaska Sea Grant College Program, 57-68, 2006.
Wittenberg E, Lichter EL, Ganz ML, McCloskey LA.
Community preferences for health states associated with intimate partner violence.
Medical Care 2006;44:738-744.
McCloskey LA, Lichter E, Williams C, Gerber M, Wittenberg E, Ganz M.
Assessing intimate partner violence in health care settings leads to women's receipt of interventions and improved health.
Public Health Reports 2006;121:435-44.
Mattsson N, Duvevik EG, Pelsue SC. Expansion of CD22lo B cells in the spleen of autoimmune-prone flaky skin mice. Cellular Immunology 2005;234:124-132.
Welner R, Swett D, Pelsue SC. Age-related loss of bone marrow pre-B- and immature B-lymphocytes in the autoimmune-prone flaky skin mutant mice. Autoimmunity 2005;38:399-408.
Helms C, Pelsue SC, Cao L, Lamb E, Loffredo B, Taillon-Miller B, Herrin B, Burzenski LM, Gott B, Lyons BL, Keppler D, Shultz LD, Bowcock AM. The Tetratricopeptide repeat domain 7 gene is mutated in flaky skin mice: a model for psoriasis, autoimmunity and anemia. Experimental Biology and Medicine 2005;230:659-667.
Xie H, Wise SS, Holmes AL, Wakeman TP, Pelsue SC, Singh NP, Wise JP Sr. Carcinogenic lead chromate induces DNA double-strand breaks in human lung cells. Mutation Research, 2005;586:160-172.
Bernstein JL, Concannon P, Langholz B, Thompson WD, Bernstein L, Stovall M, Thomas DC; WECARE Study Collaborative Group.
Multi-center screening of mutations in the ATM gene among women with breast cancer - the WECARE Study.
Radiation Research 2005;163:698-699.
Holmes AL, Wise SS, Xie H, Gordon N, Thompson WD, Wise JP Sr.
Lead ions do not cause human lung cells to escape chromate-induced cytotoxicity.
Toxicology and Applied Pharmacology 2005;203:167-76.
Wise SS, Holmes AL, Moreland JA, Xie H, Sandwick SJ, Stackpole MM, Fomchenko E, Teufack S, May AJ Jr, Katsfis SP, Wise JP Sr.
Human lung cell growth is not stimulated by lead ions after lead chromate-induced genotoxicity.
Molecular and Cellular Biochemistry 2005;279:75-84.
McCloskey LA, Lichter E, Ganz ML, Williams CM, Gerber MR, Sege R, Stair T, Herbert B.
Intimate partner violence and patient screening across medical specialties.
Academy of Emergency Medicine 2005;12:712-722.
Gerber MR, Ganz ML, Lichter E, Williams CM, McCloskey LA.
Adverse health behaviors and the detection of partner violence by clinicians.
Archives of Internal Medicine 2005;165:1016-1021.
Tippy K, Meyer K, Aronson R, Wall T.
Characteristics of coordinated ongoing comprehensive care within a medical home in Maine.
Maternal and Child Health Journal 2005;9:S13-21.
Research Areas
Molecular Microbiology and Epidemiology of Infectious Disease
Biology and molecular genetics of gammaherpesviruses
Developmental biology of Leishmania species
Microbial and bacteriophage ecology and bacterial disease emergence
Molecular Immunology
Environmental and genetic requirements for lymphocyte development
Regulatory pathways of lymphocyte activation
Effects of chemical toxicants on inflammatory responses and the development of
autoimmunity, hypersensitivity, and cancer
Cell-Cell and Cell-Matrix/Substratum Interactions
Roles of osteopontins and selected surface protease, integrins, and selectins in:
a) Tumor immunity, tumor diagnosis, and tumor metastasis
b) Biomarkers in cardiovascular disease
Epidemiology and Epidemiologic Methods
Risk factors for breast cancer, including reproduction and familial patterns of cancer
Statistical analysis in epidemiology
Evaluation of gene-environment interactions
Effects of measurement error in epidemiologic research
Ecologic analysis
Environmental and Genetic Toxicology
Human toxicology- chromium, uranium, arsenic, ambient particulate matter studies
Marine toxicology- Bowhead Whales, Right Whales, Stellar Sea Lions
Marine research resources -- National Marine Mammal Cell Line Library
Comparative toxicology of humans and marine animals
Molecular epidemiology
Risk assessment using cell culture methods
Nanotoxicology
Educational Research
Development, assessment, and dissemination of effective departmental efforts in:
a) Laboratory-based educational outreach
b) Professional development for teachers
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