Publications

Published Papers

(1991-1995 | 1996-2000 | 2001-2005 | 2006-2010) Published Abstracts

1991-1995

Wise, J.P., Leonard, J.C., and Patierno, S.R. Clastogenicity of Lead Chromate Particles in Hamster and Human Cells. Mutation Research 278:69-79, 1992.

Xu, J., Wise, J.P., and Patierno, S.R. DNA Damage Induced by Carcinogenic Lead Chromate Particles in Cultured Mammalian Cells. Mutation Research 280:129-136, 1992.

Wise, J.P., Orenstein, J.M., and Patierno, S.R. Inhibition of Lead Chromate Clastogenesis by Ascorbate: Relationship to Particle Dissolution and Uptake. Carcinogenesis 14:429-434, 1993.

Clawson, G.A., Norbeck, L.L., Wise, J.P., and Patierno, S.R. An Inhibitor of Nuclear Scaffold Protease Blocks Chemically Induced Transformation of Embryonic Fibroblasts. Cell Growth and Differentiation 4:589-594, 1993.

Wise, Sr., J.P., Stearns, D.M., Wetterhahn, K.E., and Patierno, S.R. Cell-Enhanced Dissolution of Carcinogenic Lead Chromate Particles: The Role of Individual Dissolution Products in Clastogenesis. Carcinogenesis 15:2249-2254, 1994.

Manning, F.C.R., Blankenship, L., Wise, J.P., Xu, J., Bridgewater, L.C., and Patierno, S.R. Induction of Internucleosomal Fragmentation by Carcinogenic Chromate: Relationship to Genotoxicity, Cell Cycle Delay, and Inhibition of Macromolecular Synthesis. Environmental Health Perspectives 102:159-167, 1994.

Patierno, S.R., Blankenship, L.J., Wise, J.P., Xu, J., Bridgewater, L.C., and Manning, F.C.R. Genotoxin-Induced Apoptosis: Implications for Carcinogenesis. In: Hu, V.W. (Ed), The Cell Cycle: Regulators, Targets and Clinical Applications. Plenum Press, pp. 331-340, 1994.

1996-2000

Stearns, D.M., Wise, Sr., J.P., Patierno, S.R., and Wetterhahn, K.E. Chromium (III) Picolinate Produces Chromosome Damage in Chinese Hamster Ovary Cells. The FASEB Journal 9:1643-1648, 1995.

Blankenship, J.J., Carlisle, D., Wise, Sr., J.P., Orenstein, J.M., Dye, L.E., and Patierno, S.R. Induction of Apoptotic Cell Death by Particulate Lead Chromate: Differential Effects of Vitamins C and E on Genotoxicity and Survival. Toxicology and Applied Pharmacology 146:270-280, 1997.

Wise, Sr., J.P., and Stearns, D.M. Chromium carcinogenicity: The Roles of Valence State and Solubility. Occupation and Environmental Medicine Report 11(11):100-103, 1997.

Borak J., and Wise, J.P. DNA-Protein Crosslinks as Biomarkers of Formaldehyde Exposure. International Journal of Occupational and Environmental Health 3(4):307, 1997.

Borak J., and Wise, Sr., J.P. Does Aluminum Exposure of Pregnant Animals Lead to Accumulation in Mothers or Their Offspring? Teratology 57:127-139, 1998.

2001-2005

Wise, J., and Lechner, J.F. Normal Human Bronchial Epithelial Cell Culture. Chapter 8 in Freshney, R.I. and Freshney, M.G. (eds.) Culture of Epithelial Cells: A Manual of Technique. Wiley Inc, New York, NY. 2001.

Wise, Sr., J.P., Winn, R.N., and Renfro, J.L. Generating New Marine Cell Lines and Transgenic Species. Journal of Experimental Zoology 292:271-220, 2002.

Wise, Sr., J.P., Wise, S.S., and Little, J.E. The Cytotoxicity and Genotoxicity of Particulate and Soluble Hexavalent Chromium in Human Lung Cells. Mutation Research 517:221-229, 2002.

Rabinowitz, P.M., Wise, Sr., J.P., Antonucci, P.G., and Mobo, B.H. Glutathione-S-Transferase Polymorphism and High Frequency Otoacoustic Emissions in Noise-Exposed Workers. Hearing Research 173:164-171, 2002.

Zheng, T., Holford, T.R., Zahm, S.H., Owens, P.H., Boyle, P., Zhang, Y., Wise, Sr., J.P., Stephenson, L.P., and Ali-Osman, F. Cigarette Smoking, Glutathione S-Transferase M1 and T1 Genetic Polymorphisms, and Breast Cancer Risk (United States). Cancer Causes Control 13:637-645, 2002.

Zheng, T., Holford, T.R., Zahm, S.H., Owens, P.H., Boyle, P., Zhang, Y., Wise, Sr., J.P., and Ali-Osman, F. Glutathione S-transferase M1 and T1 Genetic Polymorphisms, Alcohol Consumption and Breast Cancer Risk. British Journal of Cancer 88:58-62, 2003.

Zheng, T., Boyle, P., Zhang, B., Zhang, Y., Owens, P.H., Lan, Q., and Wise, J. Tobacco Use and Risk of Oral Cancer . In: Boyle P, ed. Tobacco: The Public Health Disaster of the 20th Century. Oxford University Press, Oxford, UK., 2003

Wise, S.S., Elmore, L.W., Holt, S.E., Little, J.E., Antonucci, P.G., Bryant, B.H., and Wise, Sr., J.P. Telomerase-Mediated Lifespan Extension of Human Bronchial Cells Does Not Affect Hexavalent Chromium-Induced Cytotoxicity or Genotoxicity. Molecular and Cellular Biochemistry 255:103-111, 2004.

Wise, S.S., Schuler, J.H.C., Katsifis, S.P., and Wise, Sr., J.P. Barium Chromate Is Cytotoxic and Genotoxic to Human Lung Cells. Environmental and Molecular Mutagenesis 42:274-278, 2004.

Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Fomchenko, E., Katsifis, S.P., Thompson, W.D., and Wise, Sr., J.P. Chromium Is the Proximate Clastogenic Species for Lead Chromate-Induced Clastogenicity in Human Bronchial Cells. Mutation Research 560:79-89, 2004.

Wise, S.S., Schuler, J.H.C., Holmes, A.L., Katsifis, S.P., Ketterer, M.E., Hartsock, W.J., Zheng T., and Wise, Sr., J.P. A Comparison of Two Carcinogenic Particulate Hexavalent Chromium Compounds: Barium Chromate Is More Genotoxic than Lead Chromate in Human Lung Cells. Environmental and Molecular Mutagenesis 44:156-162, 2004.

Zhang, Y, Wise, Sr., J.P., Holford, T.R., Xie, H., Boyle, P., Zahm, S.H., Zou, K.Y., Zhang B., Owens, P.H., and Zheng, T. Serum Polychlorinated Biphenyls, Cytochrome P4501A1 Polymorphisms, and Risk of Breast Cancer in Connecticut Women. American Journal of Epidemiology 160(12):1177-1183, 2004.

Xie, H., Holmes, A.L., Wise, S. S., Gordon, N., and Wise, Sr., J.P. Lead Chromate-Induced Chromosome Damage Requires Extracellular Dissolution to Liberate Chromium Ions but Does Not Require Particle Internalization or Intracellular Dissolution. Chemical Research in Toxicology 17(10):1362-1367, 2004.

O’Hara, T., P. Hoekstra, C. Rosa, L. Dehn, D. Muir, V. Woshner, J. Wise, G. Ylitalo, D. Wetzel, G. Bratton. Bowhead Whale Contaminants: A Review of Current State of Knowledge and Possible Future Research Directions. SC/56/E1 at the International Whaling Commission Scientific Committee: 29 June to 10 July, Sorrento, Italy, p. 16, 2004.

Holmes, A.L., Wise, S. S., Xie, H., Gordon, N., Thompson W.D., and Wise, Sr., J.P. Lead Ions Do Not Cause Human Lung Cells to Escape Chromate-Induced Cytotoxicity. Toxicology and Applied Pharmacology 203:167–176, 2005.

Xie, H., Wise, S. S., Holmes, A.L., Xu, B., Wakeman, T., Pelsue, S.C., Singh, N.P., and Wise, Sr., J.P. Carcinogenic Lead Chromate Induces DNA Double-Strand Breaks in Human Lung Cells. Mutation Research 586(2):160-172, 2005.

Wise, S.S., Holmes, A.L., Moreland, J.A., Xie, H., Sandwick, S.J., Stackpole, M.M., Fomchenko, E., Teufack, S., May, Jr., A.J., Katsifis, S.P., and Wise, Sr., J.P. Human Lung Cell Growth Is Not Stimulated by Lead Ions after Lead Chromate-Induced Genotoxicity. Molecular and Cellular Biochemistry 279 (1-2):75-84, 2005.

Wise, Sr., J.P. Lobster Shell Disease Workshop. Environmental contaminants: A Potential Confounding Factor to Lobster Shell Disease in the American Lobster (Homarus americanus) Aquatic Forum Series 05-1. Tlusty, M.F., Halvorson, H.O., Smolowitz, R., and Sharma, U. (eds.) New England Aquarium, Boston Massachusetts. 2005.

2006-2010

Grlickova-Duzevik E., Wise, S.S., Munroe, R.C., Thompson, W.D., and Wise, J.P., Sr. XRCC1 Protects Against Particulate Chromate-Induced Chromosome Damage and Cytotoxicity in Chinese Hamster Ovary Cells. Toxicological Sciences, 92(1): 96-102, 2006.

Holmes, A.L., Wise, S. S., Sandwick, S.J., Lingle, W.L., Negron, V.C., Thompson W.D., and Wise, Sr., J.P. Chronic Exposure to Lead Chromate Causes Centrosome Abnormalities and Aneuploidy in Human Lung Cells. Cancer Research 66(8):4041-4048, 2006.

Wise, Sr., J.P., Goertz, C.E.C., Wise, S.S., Morin, A.T., Dunn, J.L., Gulland, F.M.D., Bozza, M., Atkinson, S., and Thompson, W.D. Chromium Cytotoxicity in Steller Sea Lion Lung, Skin and Testes Cells. In Trites, A.W., Atkinson, S.K., DeMaster, D.P., Fritz, L.W., Gelatt, T.S., Rea, L.D., and Wynne, K.M. (Eds), Sea Lions of the World Conservation and Research in the 21st Century. Alaska Sea Grant College Program, pp. 57-68, 2006.

Godard, C.A.J., Wise, S.S., Kelly, R.S., Goodale, B., Kraus, S., Romano, T., O’Hara, T., and Wise, Sr., J.P. Benzo[a]pyrene Cytotoxicity in Right Whale (Eubalaena glacialis) Skin, Testis and Lung Cell Lines. Marine Environmental Research 62:S20-S24, 2006.

Duzevik, E.G., Wise, S.S., Munroe, R.C., Thompson, W.D., and Wise, Sr., J.P. XRCC1 Protects against Particulate Chromate-Induced Chromosome Damage and Cytotoxicity in Chinese Hamster Ovary Cells. Toxicological Sciences 92(2):409-415, 2006.

Wise, S.S., Holmes, A.L., and Wise, Sr., J.P. Particulate and Soluble Hexavalent Chromium Are Cytotoxic and Genotoxic to Human Lung Epithelial Cells. Mutation Research, 610(1-2): 2-7, 2006.

Holmes, A.L., Wise, S. S., Sandwick, S.J., and Wise, Sr., J.P. The Clastogenic Effects of Chronic Exposure to Particulate and Soluble Cr(VI) in Human Lung Cells. Mutation Research, 610(1-2): 8-13, 2006.

Grlickova-Duzevik, E., Wise, S.S., Munroe, R.C., Thompson, W.D., and Wise, J.P., Sr. XRCC1 Protects Cells from Chromate-Induced Chromosome Damage, but Does Not Affect Cytotoxicity. Mutation Research, 610(1-2): 610:31-37, 2006.

Wise, S.S., Holmes, A.L., Xie, H., Thompson, W.D., and Wise, Sr., J.P. Chronic Exposure to Particulate Chromate Induces Spindle Assembly Checkpoint Bypass in Human Lung Cells. Chemical Research in Toxicology, 19(11):1492-1498, 2006.

Wise, Sr., J.P. Genotoxic and Carcinogenic Effects of Lead. In, U.S. EPA. Air Quality Criteria for Lead (Final). U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-05/144aF-bF, 5-125 – 5-147, 2006.

Savery, L.C., Grlickova-Duzevik, E., Wise, S.S., Thompson, W.D., Hinz, J.M., Thompson, L.H., and Wise, Sr., J.P. Role of the Fancg Gene in Protecting Cells from Particulate Chromate-Induced Chromosome Instability. Mutation Research, 626(1-2): 120-127, 2007.

Camrye, E., Wise, S.S., Milligan, P., Gordon, N., Goodale, B., Stackpole, M., Patzlaff, N.,  Aboueissa, A., and Wise, Sr., J.P. Ku80 Deficiency Does Not Affect Particulate Chromate-Induced Chromosome Damage and Cytotoxicity in Chinese Hamster Ovary Cells. Toxicological Sciences, 97(2):348-54, 2007.

Wise, S.S., Thompson, W.D., Aboueissa, A., Mason, M.D., and Wise, Sr., J.P. Particulate Depleted Uranium Is Cytotoxic and Clastogenic to Human Lung Cells. Chemical Research in Toxicology, 20(5):815-820, 2007.

Zhang, Y., Holford, T.R., Leaderer, B.,Boyle, B., Zhu, Y., Wang, R., Zou, K., Zhang, B., Wise, Sr., J.P., Qin, Q., Kilfoy, B., Han, J., and Zheng, T. Ultraviolet Radiation Exposure and Risk of Non-Hodgkin Lymphoma. American Journal of Epidemiology, 165(11):1255-64, 2007.

Wise, J. Hexavalent Chromium Compounds. In: Schwab M. (ed). Encyclopedia of Cancer, 2nd edn. Springer, Berlin Heidelberg New York (in press)

Stackpole, M.M., Wise, S.S., Duzevik, E.G., Munroe, R.C., Thompson, W.D., Thacker, J., Thompson, L.H., Hinz, J.M., and Wise, Sr., J.P. Homologous Recombination Protects Against Particulate Chromate-Induced Genomic Instability in Chinese Hamster Cells. Mutation Research. 625: 145-154, 2007.

Xie, H., Holmes, A.L., Wise, S.S., Huang, S., Peng, C., and Wise, Sr., J.P. Neoplastic Transformation of Human Bronchial Cells by Lead Chromate Particles. American Journal of Respiratory Cell and Molecular Biology. 37(5): 544-552, 2007.

Xie, H., Wise, S.S., and Wise, Sr., J.P. Deficient Repair of Particulate Chromate-Induced DNA Double Strand Breaks Leads To Neoplastic Transformation. Mutation Research. 649: 230-238, 2008.

Wise, Sr. J.P., Wise, S.S, Kraus, S. Shaffiey, F., Grau, M., Li Chen, T., Perkins, C., Thompson, W.D., Zheng, T., Zhang, Y., Romano, T., and O’Hara, T. Hexavalent Chromium Is Cytotoxic and Genotoxic to the North Atlantic Right Whale (Eubalaena glacialis) Lung and Testes Fibroblasts. Mutation Research. In Press.

Published Abstracts (return to top)

(1991-1995 | 1996-2000 | 2001-2005 | 2006-2010)

1991-1995

Patierno, S.R., Dirscherl, L., and Wise, J.P. Mitogenesis and Clastogenesis of Particulate Metal Carcinogens in Respiratory Epithelial Cells. The FASEB Journal Abstracts 5: 7156, 1991.

Wise, J.P., Leonard, J.C., and Patierno, S.R. Clastogenesis of Lead Chromate (PbCrO4) Particles in Hamster and Human Cells. Proceedings of the American Association for Cancer Research 32: 635, 1991.

Wise, J.P., Xu, J., and Patierno, S.R. Relationship of Chromate-Induced DNA Damage to Chromosomal Aberrations. The Toxicologist 12: 1201, 1992.

Manning, FC.R., Blankenship, L.J., Wise, J.P., Xu, J., Bridgewater, L.C., and Patierno, S.R. Induction of Apoptosis by Carcinogenic Chromate: Relationship to Genotoxicity, Cell Cycle Delay, and Inhibition of Macromolecular Synthesis. Proceedings, Second International Meeting on Molecular Mechanisms of Metal Toxicity and Carcinogenicity, 1993.

Wise, J.P., Orenstein, J.M., and Patierno, S.R. Inhibition of Lead Chromate Clastogenesis by Ascorbate: Relationship to Particle Dissolution and Uptake. Proceedings of the American Association for Cancer Research 34: 3316, 1993.

Stearns, D.M., Wise, Sr., J.P., Patierno, S.R., and Wetterhahn, K.E. The Dietary Supplement Chromium Picolinate Induces Chromosome Damage in Chinese Hamster Ovary Cells. The FASEB Journal Abstracts 9(3): A451, 1995.

Blankenship, L.J., Wise, J.P., Orenstein, J.M., and Patierno, S.R. Vitamin Pretreatment Protects Cells from Chromium-Induced Apoptosis without Decreasing Chromium-Induced DNA Adducts. Proceedings of the American Association for Cancer Research 36: 68, 1995.

1996-2000

Wise, Sr., J.P., Caporasso, N.E., Trivers, G.E., Tucker, M.A., Trump, B.F., Harris, C.C., and Shields, P.G. Glutathione-S-Transferase Theta (GST-T) and Lung Cancer Risk. Proceedings of the American Association for Cancer Research Conference on Cancer Susceptibility Genes and Molecular Carcinogenesis Meeting, February 1996.

Wise, Sr., J.P., Caporasso, N.E., Trivers, G.E., Tucker, M.A., Trump, B.F., Harris, C.C., and Shields, P.G. The relationship of Glutathione-S-Transferase Theta (GST-T) Polymorphism to Lung Cancer Risk. Proceedings of the American Association for Cancer Research, 37: 1784, 1996.

Hussain, S.P., Amstad, P., Ambs, S., Bennett, W.P., Wise, Sr., J.P., Harrington, A., Shields, P.G., and Harris, C.C. P53 Mutation Load Is Increased in Ulcerative Colitis, a Cancer-Prone Disease. Proceedings of the American Association for Cancer Research, 37:963, 1996.

May, Jr., A.J., Wise, S.S., Stearns, D.M., Ketterer, M.E., Wise, Sr., J.P. Particulate Hexavalent Chromium and Human Health in The Arctic. Proceedings of the American Association for the Advancement of Science Meeting, September 1999.

May, Jr., A.J., Wise, S.S., Stearns, D.M., Ketterer, M.E., and Wise, Sr., J.P. Differential Effects of Particulate and Soluble Hexavalent Chromium on the Cell Cycle. Proceedings of the American Association for Cancer Research Conference on the Genetic and Functional Consequences of Cell Cycle Alteration in Cancer, October 1999.

Rabinowitz, P.M., Wise, Sr., J.P., Antonucci, P.G., and Mobo, B.H. Glutathione-S-Transferase M1 (GSTM1) and T1(GSTT1) as Predictors of Susceptibility to High Frequency Hearing Changes in Noise-Exposed Workers. Proceedings of the Environmental Carcinogenesis Population Risk and Genetic Susceptibility Meeting, October, 2000.

Wise, S.S., Elmore, L.W., Antonucci, P.G., Holt, S.E., Bryant, B.H., and Wise, Sr., J.P. A Human Bronchial Cell Model for Lung Carcinogens. Proceedings of the Northeast Society of Toxicology Meeting, October 2000.

Wise, S.S., Elmore, L.W., Antonucci, P.G., Holt, S.E., Bryant, B.H., and Wise, Sr., J. P. Establishing a Human Bronchial Cell Culture Model for Lung Carcinogens. Proceedings of the American College of Toxicology Annual Meeting, November 2000.

2001-2005

Wise, S.S., Ketterer, M.E., Antonucci, P.G., and Wise, Sr., J.P. Genotoxic Effects of Particulate and Soluble Cr(VI) in a Human Bronchial Cell Culture Model. Environmental Molecular Mutagenesis, 37:80, 2001.

Wise, Sr., J.P., Wise, S.S., Elmore, L.W., Antonucci, P.G., and Holt, S.E. Establishing Continuous Human Cell Lines with hTERT. Proceedings of the Mount Desert Island Biological Laboratory Meeting on Marine Models, May 2001.

Wise, Sr., J.P., Wise, S.S. and St. Aubin, D.J. Establishing Continuous Cell Lines in Three Marine Species Delphinus delphius, Tursiops truncatus, and Delphinapterus leucas. Proceedings of the Mount Desert Island Biological Laboratory Meeting on Marine Models, May 2001.

Wise, Sr., J.P., Wise, S.S. and St. Aubin, D.J. Establishing Cultures of Bronchial Cells from the Common Dolphin (Delphinus delphis). Society of Environmental Chemistry and Toxicology (SETAC) Abstracts p. 158, 2001.

Bidulescu, A, Wise, S.S., May, A., Tang, E.R., Bryant, B.H., Schumm, K.R., and Wise, Sr., J.P. A Comparison of Chromium Toxicity in Three Cell Culture Models. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2001.

Wise, S.S., and Wise, Sr., J.P. The Cytotoxicity and Clastogenicity of Particulate and Soluble Hexavalent Chromium in Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2001.

Wise, Sr., J.P., Antonucci, P.G., and Bryant, B.H. Toxicology of Hexavalent Chromium in Five Marine Animals: Bowhead Whale, (Balaena mysticetus), Beluga Whale (Delphinapterus leucas), Little Skate (Raja erinacea), Spiny Dogfish (Squalus acanthias) and the Killifish (Fundulus heteroclitus). The Bulletin 40:29-30, 2001.

Bidulescu, A, Wise, S.S., May, A., Tang, E.R., Bryant, B.H., Schumm, K.R., and Wise Sr., J.P. Hexavalent Chromium Toxicity in Human Lung Cells, Chinese Hamster Ovary Cells and A549 Cells: Current Cell Culture Models Are Inadequate. Toxicological Sciences 66(S):32 (150), 2002.

Wise, S.S., Elmore, L.W., Antonucci, P.G., Holt, S.E., Bryant, B.H., and Wise, Sr., J.P. A New Human Bronchial Cell Culture Model for Investigating Metal-Induced Lung Carcinogenesis. Toxicological Sciences 66(S):32 (151), 2002.

Antonucci, P.G., Wise, S.S., Pincavage, A., Singh, N.P., and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Cr(VI) in Human Bronchial Cells. Toxicological Sciences 66(S):32 (152), 2002.

Little, J.E., Wise, S.S., and Wise, Sr., J.P. The Genotoxicity of Particulate and Soluble Hexavalent Chromium in Human Bronchial Cells. Toxicological Sciences 66(S):32 (LB16), 2002.

Barnes, D.W., Forrest Jr, J.N., Wise, Sr., J.P., and Winn, R.N. Derivation of Continuous Marine Cell Lines for Model Systems in Toxicology and Cell Biology. The Bulletin, 41:45-47, 2002.

Wise, Sr., J.P., Antonucci, P.G., Holt, S.E., Elmore, L.W., Forrest, Jr., J.N., Boyer, J., and Bryant, B.H. Establishing Cell Lines In Four Marine Species: Bowhead Whale, (Balaena mysticetus), Beluga Whale (Delphinapterus leucas), Little Skate (Raja erinacea), and Spiny Dogfish (Squalus acanthias). The Bulletin 41:48-49, 2002.

Wise, S.S., Elmore, L.W., Antonucci, P.G., Holt, S.E., Little, J.E., Bryant, B.H., and Wise, Sr., J. P. Establishing a New Lung Cell Culture Model for Studying Carcinogenic Metals. Proceedings of the 2nd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis, September, 2002

Holmes, A.L., Wise, S.S., Ketterer, M.E., Xie, H., Hartsock, W.J., Shuler, J.H.C., Katsifis, S.P., and Wise, Sr., J.P. Barium Chromate Is More Potent Than Lead Chromate in Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2002.

Shuler, J.H.C., Wise, S.S., Katsifis, S.P., and Wise, Sr., J.P. The Cytotoxicity and Clastogenicity of Barium Chromate in Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2002.

Moreland, J.A., Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Thomas, R.A., Fomchenko, E., Katsifis, S.P., and Wise, Sr., J.P. Lead Chromate-Induced Cell Cycle Arrest Progresses From G1 to S-Phase Arrest With Increasing Concentrations. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2002.

Lynch, J.P, Little, J.E., Wise, S.S., Slotnick, M.J., and Wise, Sr., J.P. Comparative Genotoxicity of Arsenic, Cadmium and Chromium in Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2002.

Xie, H., Wise, S.S., Holmes, A.L, Ketterer, M.E., Hartsock, W.J., and Wise, Sr., J.P. Particle Dissolution Is Necessary For Lead Chromate-Induced Genotoxicity in Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2002.

Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Fomchenko, E., Katsifis, S.P., and Wise, Sr., J.P. Lead Chromate-Induced Genotoxicity Is Mediated by Chromium and Not Lead in Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2002.

Wise, S.S., Elmore, L.W., Holt, S.E., Little, J.E., Bryant, B.H., and Wise, Sr., J. P. Ectopic Expression of hTERT in Human Bronchial Cells Extends Cellular Lifespan without Affecting Hexavalent Chromium-Induced Cytotoxicity or Genotoxicity. Proceedings of the American Association for Cancer Research Conference on the Role of Telomeres and Telomerase in Cancer, December, 2002.

Wise, Sr., J.P., Holmes, A. L., Wise, S.S., Little, J.A., Xie, H., Bozza, M., Moreland, St. Aubin, D.K., Dunn, J.L., Atkinson, S., Gulland, F., and Bursian, S. Hexavalent Chromium Cytotoxicity Is Organ and Species Specific for Steller Sea Lion and Mink Cells. Proceedings of the EVOS-GEMS/GLOBE /NMFS Steller Sea Lion Research Symposium, January 2003.

Holmes, A.L., Wise, S.S., Ketterer, ME, Xie, H, Hartsock, W, Shuler, J., Katsifis, S., and Wise, Sr., J.P. Comparative Genotoxicity of Two Particulate Hexavalent Chromium Compounds in Human Bronchial Cells. Toxicological Sciences 72(S):218, 2003.

Wise, S.S., Holmes, A, Ketterer, M.E., Hartsock, W.J., Fomchenko, E., Katsifis, S., and Wise, Sr., J.P. Chromium Is the Proximate Genotoxic Species in Lead Chromate-Induced Clastogenicity in Human Bronchial Cells. Toxicological Sciences 72(S):217, 2003.

Shuler, J.H.C., Wise, S.S., Katsifis, S., and Wise, Sr., J.P. Barium Chromate is Cytotoxic and Clastogenic to Human Bronchial Cells. Toxicological Sciences 72(S):218, 2003.

Moreland, J.A., Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Thomas, R.A., Fomchenko, E., Katsifis, S.P., and Wise, Sr., J.P. The Phase of Lead Chromate Induced Cell Cycle Arrest Is Concentration Dependent. Toxicological Sciences 72(S):218, 2003.

Little, J.E., Wise, S.S., Slotnick, M.J, and Wise, Sr., J.P. Cytotoxicity and Clastogenicity of Arsenic, Cadmium and Chromium in Human Bronchial Cells. Toxicological Sciences 72(S):219, 2003.

Xie, H, Wise, S.S., Holmes, A, Ketterer, M.E., Hartsock, W.J., and Wise, Sr., J.P. Lead Chromate Genotoxicity Is Mediated by Particle Dissolution and Not Particle Internalization. Toxicological Sciences 72(S):217, 2003.

Goertz, C.E.C., Wise, S.S., Dunn, J.L., and Wise, Sr., J.P. Cell Culture, Toxicology, and Stranded Marine Mammals. Proceedings of the Maine Biotechnology Association Annual Meeting, April, 2003.

Moreland, J.A., Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Thomas, R.A., Fomchenko, E., Katsifis, S.P., and Wise, Sr., J.P. The Phase of Lead Chromate Induced Cell Cycle Arrest Is Concentration Dependent. Proceedings of the Maine Biotechnology Association Annual Meeting, April, 2003.

Goertz, C.E.C., Wise, S.S., Dunn, J.L., and Wise, Sr., J.P. Cell Culture, Toxicology, and Stranded Marine Mammals. Proceedings of the Northeast Region Stranding Network, April, 2003.

Lynch, J.P, Little, J.E., Wise, S.S., Slotnick, M.J, and Wise, Sr., J.P. Comparative Genotoxicity of Arsenic, Cadmium and Chromium in Human Bronchial Cells. Proceedings of the Maine Biological and Medical Sciences Annual Symposium, April, 2003.

Xie, H., Wise, S.S., Holmes, A.L, Ketterer, M.E., Hartsock, W.J., and Wise, Sr., J.P. Particle Dissolution Is Necessary for Lead Chromate-Induced Genotoxicity in Human Bronchial Cells. Proceedings of the Maine Biological and Medical Sciences Annual Symposium, April, 2003.

Holmes, A.L., Goertz, C.E.C., Wise, S.S., Little, J.E., Moreland, J.A., Bozza, M., St. Aubin, D.K., Dunn, J.L., Atkinson, S., Gulland, F., and Wise, Sr., J.P. Cell Culture and Toxicology of Marine Mammals. Proceedings of the Maine Biological and Medical Sciences Annual Symposium, April, 2003.

Wise, S.S., Goertz, C.E.C., Little, J.E., Bozza, M., St. Aubin, D.K., Dunn, J.L., Atkinson, S., Gulland, F., and Wise, Sr., J.P. Metal Toxicity in Cultured Steller Sea Lion Fibroblasts. Proceedings of the Annual Meeting of the International Association of Aquatic Animal Medicine, 35: 140, 2003.

Wise, Sr., J.P., Wise, S.S., Goertz, C.E.C., Thompson, M., Smith, B., O’Hara, T., St. Aubin, D.K., and Dunn, J.L. Comparative Chemical Carcinogenesis of Environmental Contaminants in Balaenidae Whales (Balaena mysticetus and Eubalaena glacialis) and Humans: Bowhead Whales Are Resistant to Hexavalent Chromium. Proceedings of the Aquatic Animal Models of Human Disease Conference, September 30, 2003.

Morin, A.T., Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F., Jayasundara, N., Bozza, M, Atkinson, S., and Wise, Sr., J.P. Comparative Cytotoxicity of Hexavalent Chromium in Humans and Steller Sea Lions. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2003.

Diaz, W.C., Wise, S.S., and Wise, Sr., J.P. The Cytotoxicity and Clastogenicity of Depleted Uranium in Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2003.

Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F., Morin, A.T., Jayasundara, N., Bozza, M., Atkinson, S., and Wise, Sr., J.P. Sodium Chromate and Cadmium Chloride Toxicity in Steller Sea Lion Dermal, Renal, Bronchial, and Testicular Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2003.

Moreland, J.A., Teufack, S., Sandwick, S., Dufour, J-F., Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Fomchenko, E., Katsifis, S.P., and Wise, Sr., J.P. Particulate Hexavalent Chromium-Induced Cell Cycle Arrest Is Mediated by Cr Ions. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2003.

Wise, S.S., Holmes, A.L., Thompson, M., Smith, B.E., O’Hara, T., and Wise, Sr., J.P. Cytotoxicity of Particulate and Soluble Hexavalent Chromium in Bowhead Whale and Human Bronchial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2003.

Xie, H., Holmes, A.L., Wise, S.S., Gordon, N., and Wise, Sr., J.P. Lead Chromate Releases Extracellular Cr Ions That Produce Its Clastogenic Effects. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, November 2003.

Wise, Sr., J.P., Wise, S.S., Goertz, C.E.C., Bozza, M., St. Aubin, D.K., Dunn, J.L., Atkinson, S., and Gulland, F. Toxicity of Heavy Metals in Cultured Steller Sea Lion Cells. Proceedings of the Society of Environmental Toxicology and Chemistry, November, 2003.

Goertz, C.E.C., Wise, S.S., Jayasundara, N., St. Aubin, D.K., Dunn, J.L., Bozza, M., Atkinson, S., Gulland, F, and Wise, Sr., J.P. Metal Toxicity in Cultured Steller Sea Lion Fibroblasts. Proceedings of the Annual Meeting of the Society of Marine Mammalogy, December 2003.

Wise, S.S., Goertz, C.E.C., Thompson, M., Smith, B., O’Hara, T., St. Aubin, D.K., and Dunn, J.L., and Wise, Sr., J.P. The Effects of Environmental Contaminants on Balaenidae Whales (Balaena mysticetus and Eubalaena glacialis): Metal Toxicity in Bowhead Whales. Proceedings of the Annual Meeting of the Society of Marine Mammalogy, December 2003.

Diaz, W.C., Wise, S.S., and Wise, Sr., J.P. The Cytotoxicity of Depleted Uranium in Human Bronchial Cells. Proceedings of the Annual Meeting of the New England Chapter of New England Pharmacologists, February, 2004.

Morin, A.T., Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F, Jayasundara, N., Bozza, M., Atkinson, S., and Wise, Sr., J.P. Comparative Cytotoxicity of Hexavalent Chromium Compounds in Humans and Steller Sea Lions. Proceedings of the Annual Meeting of the New England Chapter of New England Pharmacologists, February, 2004.

Holmes, A.L., Gordon, N., and Wise, Sr., J.P. Chromium Ions Are the Proximate Clastogenic Species for Particulate Hexavalent Chromium in Human Lung Cells. Proceedings of the Annual Meeting of the New England Chapter of New England Pharmacologists, February, 2004.

Xie, H., Wise, S.S., Holmes, A., Ketterer, M.E., Hartsock, W.J., and Wise, Sr., J.P. Particle Dissolution Is Necessary for Lead Chromate-Induced Genotoxicity in Human Bronchial Cells. Proceedings of the Annual Meeting of the New England Chapter of New England Pharmacologists, February, 2004.

Wise, S.S., Holmes, A.L., Xie, H., and Wise, Sr., J.P. The Physico-Chemical Mechanisms of Particulate Chromium (VI)-Induced Clastogenesis. Proceedings of the AACR Special Conference in Radiation Biology and Cancer, February 2004.

Holmes, A.L., Gordon, N., and Wise, Sr., J.P. Lead Chromate-Induced Cytotoxicity in Human Bronchial Cells is Mediated by Extracellular Chromium. Toxicological Sciences 67(S): 760, 2004.

Morin, A.T., Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F, Jayasundara, N., Bozza, M., Atkinson, S., and Wise, Sr., J.P. Sodium Chromate Toxicity in Bronchus and Dermis of Steller Sea Lions and Humans. Toxicological Sciences 67(S): 757, 2004.

Diaz, W.C., Wise, S.S., and Wise, Sr., J.P. Uranium is Cytotoxic and Genotoxic to Human Lung Cells. Toxicological Sciences 67(S): 272, 2004.

Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F, Morin, A., Jayasundara, N., Bozza, M., Atkinson, S., and Wise, Sr., J.P. Cytotoxicity of Two Heavy Metals in Steller Sea Lion Dermal, Renal, Bronchial, and Testicular Cells. Toxicological Sciences 67(S): 756, 2004.

Moreland, J.A., Teufack, S., Sandwick, S., Dufour, J-F., Wise, S.S., Holmes, A.L., Ketterer, M.E., Hartsock, W.J., Fomchenko, E., Katsifis, S.P., and Wise, Sr., J.P. Lead Chromate (LC) Induces Cell Cycle Arrest in WTHBF-6 Cells, However Lead Alone Is Mitogenic. Toxicological Sciences 67(S): 270, 2004.

Wise, S.S., Holmes, A.L., Thompson, M., Smith, B.E., O’Hara, T., and Wise, Sr., J.P. Comparative Chromium Toxicity in Cultured Bowhead Whale and Human Lung Cells. Toxicological Sciences 67(S): 759, 2004.

Xie, H., Holmes, A.L., Wise, S.S., Gordon, N., and Wise, Sr., J.P. Particulate Hexavalent Chromium-Induced Clastogenesis is Mediated by Extracellular Dissolution that Does Not Require Particle Cell Contact. Toxicological Sciences 67(S): 281, 2004.

Jalbert, A., Gordon, N., Langley-Turnbaugh, S., and Wise, Sr., J.P. The Effect of Urban Particulate Matter on Human Lung Cells. Toxicological Sciences 67(S): 1039, 2004.

Zhang, Y, Wise, Sr., J.P., Holford, T.R., Xie, H., Boyle, P., Zahm, S.H., Zhang B., Zou, K.Y., Owens, P.H., and Zheng, T. Polychlorinated Biphenyls, Cytochrome P4501A1 Polymorphism, and Risk of Breast Cancer in Connecticut Women. Proceedings of the American Association for Cancer Research, 45: 3729, 2004.

Wise, S.S., Holmes, A.L., Xie, H., Gordon, N., Thompson W.D., and Wise, Sr., J.P. Lead Chromate-Induced Cytotoxicity In Human Bronchial Cells Is Mediated By Extracellular Chromium and Does Not Require Functional p53 or Rb. Proceedings of the American Association for Cancer Research, 45: LB-180, 2004.

Xie, H., Moreland, J.A., Wise, S.S., and Wise, Sr., J.P. Particulate Hexavalent Chromium Induces DNA Double Strand Breaks in Human Bronchial Cells. Proceedings of the American Association for Cancer Research, 45: LB-168, 2004.

Goertz, C.E.C., Wise, S.S., Dunn, J.L., Bozza, M., Atkinson, S., Gulland, F.M.D., Taylor, R.J., and Wise, Sr., J.P. In Vitro Metal Toxicity in Steller Sea Lion (Eumetopias jubatus) Fibroblasts with an Emphasis on Hexavalent Chromium. Proceedings of the Annual Meeting of the International Association of Aquatic Animal Medicine, 35: 74-75 2004.

Wise, S.S., Holmes, A.L., Xie, H., Gordon, N., Moreland, J.A., Sandwick, S.J., Stackpole, M.M., Fomchenko, E., Teufack, S., May, Jr., A.J., Katsifis, S.P., Thompson, W.D., and Wise, Sr., J.P. Mechanisms of Particulate Chromate-Induced Genotoxicity. Proceedings of the 3rd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis. September, 2004.

Xie, H., Wise, S.S., Holmes, A.L., and Wise, Sr., J.P. Carcinogenic Lead Chromate Induces Double-Strand Breaks in Human Lung Cells. Proceedings of the 3rd Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis. September, 2004.

Goertz, C.E.C., Wise, S.S., Dunn, J.L., Gulland, F.M.D., Morin, A., Jayasundra, N., Bozza, M., Atkinson, S., and Wise, Sr., J.P. Sodium Chromate Toxicity and Uptake in Steller Sea Lion Cells. Proceedings of the 22nd Wakefield Fisheries Symposium: Sea Lions of the World Conservation and Research in the 21st Century, September, 2004.

Lynch, J.P., Wise, S.S., and Wise, Sr., J.P. Arsenic Induces Centromeric Abnormalities and Endoreduplication in Chromosomes of Human Lung Cells. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, October 2004.

Chason, J., Bodoky, A., Xie, H., Wise, S.S., Holmes, A.L., Teufack, S., Katsifis, S., and Wise, Sr., J.P. The Functional Role of NBS1 in the Repair of Cr(VI)-Induced DNA Damage. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, October 2004.

Stackpole, M.M., Wise, S.S., Duzevik, E.G., Munroe, R.C., Thompson, L.H., and Wise, Sr., J.P. Particulate Chromate-Induced Genomic Instability Is Prevented by Homologous Recombination. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, October 2004.

Duzevik, E.G., Munroe, R.C., Wise, S.S., and Wise, Sr., J.P. XRCC1 Is Involved in Repair of Lead Chromate-Induced Chromosome Damage. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, October 2004.

Sandwick, S.J., Holmes, A.L., Wise, S.S., Gordon, N., and Wise, Sr., J.P. Lead Ions Disrupt Normal Mitotic Progression in Human Lung Cells after More Chronic Exposures to Lead Chromate. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, October 2004.

Xie, H., Wise, S.S., and Wise, Sr., J.P. Carcinogenic Lead Chromate Induces DNA Double-Strand Breaks in Human Lung Cells. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, October 2004.

Van Epps, G., Jalbert, A., Alley, D., Langley-Turnbaugh, S., Gordon, N.R., and Wise, Sr., J.P. Metal Composition of Maine Particulate Matter (PM) and Effects of These Metals on Human Lung Fibroblasts. Proceedings of the Annual Meeting of the Northeast Chapter of the Society of Toxicology, October 2004.

Kelly, R., Wise, S.S., Kraus, S., O’Hara, T., Romano, T, and Wise, Sr., J.P. Development of Right Whale and Bowhead Whale Cell Lines. Proceedings of the Annual Meeting of the North Atlantic Right Whale Consortium, November 2004.

Wise, S.S., Kelly, R., Kraus, S., O’Hara, T., Romano, T., and Wise, Sr., J.P. The Effect of Environmental Contaminants on Northern Atlantic Right Whale and Bowhead Whale Cell Cultures. Proceedings of the Annual Meeting of the North Atlantic Right Whale Consortium, November 2004.

Bank, M.S., Driscoll, C., Fernandez, I., Wise, J., Amirbahman, A., and Foster, D. Effects of Disturbance Regimes on Mercury Bioaccumulation in Two-Lined Salamanders from Stream Ecosystems in the Northeastern United States. Proceedings of the Annual Meeting of the Northeast Resource Council, November 2004.

Wise, S.S., Stackpole, M.M., Duzevik, E.G., Munroe, R.C., Thompson, L.H., and Wise, Sr., J.P. Homologous Recombination Protects against Particulate Chromate-Induced Genomic Instability in Chinese Hamster Cells. Proceedings of the ASM Special Conference: DNA Repair and Mutagenesis: from Molecular Structure to Biological Consequences, November, 2004.

Van Epps, G., Langley-Turnbaugh, S., Gordon, N.R., and Wise, J.P. The Relationship between Maine Soil and PM10. Proceedings of the International Soil Science Meeting, December 2004.

Duzevik, E.G., Wise, S.S., Munroe, R.C., and Wise, Sr., J.P. Repair of Chromate-Induced Chromosome Damage Is Mediated by XRCC1. Toxicological Sciences 84(S-1):1135, 2005.

Xie, H., Wise, S.S., Holmes, A.L., and Wise, Sr., J.P. Carcinogenic Lead Chromate Induces DNA Double-Strand Breaks and Activates ATM Kinase in Human Lung Cells. Toxicological Sciences 84(S-1):1134, 2005.

Holmes, A.L., Sandwick, S.J., Wise, S.S., Gordon, N., Thompson W.D., and Wise, Sr., J.P. Chronic Exposure to Lead Ions from Lead Chromate Interferes with Normal Mitotic Progression. Toxicological Sciences 84(S-1):1145, 2005.

Wise, S.S., Holmes, A.L., Moreland, J.A., and Wise, Sr., J. P. Genotoxicity of Particulate Uranium and Chromium. Toxicological Sciences 84(S-1):160, 2005.

Lynch, J.P., Wise, S.S., and Wise, Sr., J.P. Arsenic Induces Chromosomal and Centromeric Abnormalities in Human Lung Cells. Toxicological Sciences 84(S-1):145, 2005.

Xie, H., Wise, S.S., and Wise, Sr., J.P. ATM Mediated Repair of Lead Chromate Induced DNA Double-Strand Breaks Prevents Genomic Instability in Human Lung Cells. Proceedings of the Keystone Symposia on DNA Repair, 243, 2005.

Wise, S.S., Holmes, A.L., Sandwick, S.J., Gordon, N., Thompson W.D., and Wise, Sr., J.P. Lead Ions Interfere with Repair of Particulate Chromate-induced Chromosome Aberrations Resulting in Prolonged Chromosome Instability in Human Lung Cells. Proceedings of the American Association for Cancer Research 46:3043, 2005.

Xie, H., Wise, S.S., and Wise, Sr., J.P. MRE11 Mediated Repair of Lead Chromate Induced DNA Double-Strand Breaks. Proceedings of the American Association for Cancer Research 46:3064, 2005.

Wise, S.S., Holmes, A.L., Sandwick, S.J., and Wise, Sr., J.P. Chronic Exposure to Lead Chromate Induces Premature Anaphase and Inhibits Repair of Chromosome Damage in Human Lung Cells. Proceeding of the American Thoracic Society, 2:A744, 2005.

Holmes, A.L., Wise, S.S., Morin, A.T., Goertz, C.E.C, Atkinson, S., Dunn, J.L., Gulland, F.M.D., and Wise, Sr., J.P. Sodium Chromate Toxicity in Steller Sea Lion Cells. Proceedings of the Annual Meeting of the North Atlantic Chapter of the Society for Environmental Toxicology and Chemistry, June, 2005.

Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C., and Wise, Sr., J.P. Chronic Exposure to Lead Chromate Causes Centrosome Abnormalities and Aneuploidy in Human Lung Cells. Proceedings of the Biennial Meeting of the Chromium and Human Health Workshop, August, 2005.

Wise, S.S., Holmes, A.L., Sandwick, S.J., and Wise, Sr., J.P. Lead Chromate-Induced Centromeric Abnormalities in Human Lung Cells. Proceedings of the Biennial Meeting of the Chromium and Human Health Workshop, August, 2005.

Xie, H., Wise, S.S., Holmes, A.L., and Wise, Sr., J.P. Mechanisms of Repair of Particulate Cr(VI)-Induced DNA Double Strand Breaks. Proceedings of the Biennial Meeting of the Chromium and Human Health Workshop, August, 2005.

Duzevik, E.G., Wise, S.S., Munroe, R.C., and Wise, Sr., J.P. Repair of Chromate-Induced Chromosome Damage Is Mediated by XRCC1. Proceedings of the Biennial Meeting of the Chromium and Human Health Workshop, August, 2005.

Kelly, R., Holmes, A.L., Wise, S.S., Morin, A.T., Goertz, C.E.C., Atkinson, S., Dunn, J.L., Gulland, F.M.D., and Wise, Sr., J.P. Sodium Chromate Toxicity in Steller Sea Lion Cells. Proceedings of the Biennial Meeting of the Chromium and Human Health Workshop, August, 2005.

Savery, L.C., Wise, S.S., and Wise, Sr., J.P. Particulate Chromate-Induced DNA-DNA Crosslinks Do Not Lead to Chromosome Damage. Proceedings of the Biennial Meeting of the Chromium and Human Health Workshop, August, 2005.

Godard, C.A.J., Wise, S.S., Kelly, R.S., Goodale, B., Kraus, S., Romano, T., O’Hara, T. and Wise, Sr., J.P. Benzo[a]pyrene Cytotoxicity in Right Whale (Eubalaena Glacialis) Skin, Testis and Lung Cell Lines. Proceedings of the Biennial Meeting of PRIMO (Pollution Research in Marine Organisms), June, 2005.

Wise, S.S., Morin, A.T., Goertz, C.E.C., Dunn, J.L., Gulland, F.M.D., Bozza, M., Atkinson, S., and Wise, Sr., J.P. Metal Toxicity of Sodium Chromate in Steller Sea Lion Bronchus and Dermis Compared To Humans. Proceedings of the Biennial Meeting of PRIMO (Pollution Research in Marine Organisms), June, 2005.

Wise, S.S., Stackpole, M.M., Camyre, E., Duzevik, E.G., and Wise, Sr., J.P. Non-Homologous End Joining and Homologous Recombination Repair Protect Against Particulate Chromate-Induced Chromosome Instability. Proceedings of the International Conference on Environmental Mutagens and the Annual Meeting of the Environmental Mutagenesis Society, Mutation Research, 577 (1-2): 413, 2005.

Kelly, R.S., Wise, S.S., Kraus, S., Romano, T., O’Hara, T. and Wise, Sr., J.P. Establishment and Immortalization of Whale Cell Lines. Proceedings of the North Atlantic Right Whale Consortium, November, 2005.

Wise, S.S., Kelly, R.S., Kraus, S., O’Hara, T., Romano, T., and Wise, Sr., J.P. Tributyltin and Hexavalent Chromium Are Cytotoxic and Genotoxic to the North Atlantic Right Whale (Eubalaena glacialis). Proceedings of the North Atlantic Right Whale Consortium, November, 2005.

Godard, C.A.J., Wise, S.S., Kelly, R.S., Goodale, B., Kraus, S., Romano, T., O’Hara, T. and Wise, Sr., J.P. The Cytotoxicity of Benzo[a]pyrene in Reproductive and Somatic Cells from the Northern Right Whale (Eubalaena glacialis). Proceedings of the Annual Meeting of the North Atlantic Right Whale Consortium, November, 2005.

Wise, S.S., Kelly, R.S., Kirstein, D.P., Romano, T., and Wise, Sr., J.P. The National Marine Cell Line Library Repository. Proceedings of the International Environmental Specimen Bank Symposium, November, 2005.

Godard, C.A.J., Wise, S.S., Kelly, R.S., Goodale, B., Kraus, S., Romano, T., O’Hara, T. and Wise, Sr., J.P. Clonogenic Toxicity of Benzo[a]pyrene Is Higher in Reproductive Tissue than in Somatic Tissues of the North Atlantic Right Whale (Eubalaena glacialis). Proceedings of the biennial meeting of Society for Marine Mammalogy, December, 2005.

Wise, S.S., Kelly, R.S., Kraus, S., O’Hara, T., Romano, T., and Wise, Sr., J.P. The Effect of Environmental Contaminants; Chromium, Mercury and Tributyltin, on Bowhead and Northern Atlantic Right Whale Cells. Proceedings of the biennial meeting of Society for Marine Mammalogy, December, 2005.

2006-2010

Wise, S.S., Pfefferle, L., Goodale, B., Bresler, A., Ng, A., and Wise, Sr., J.P. The Genotoxicity of Carbon Single-Walled Nanotubes in Human Bronchial Cells. Proceedings of the international symposium: Nanotoxicology Biomedical Aspects, January, 2006.

Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C., and Wise, Sr., J.P. Chronic Exposure to Lead Chromate Causes Centrosome Amplification and Aneuploidy in Human Lung Cells. Toxicological Sciences 90: 519, 2006.

Xie, H, Deko, S., Wise, S.S., Katsifis, S., and Wise, Sr., J.P. ATM and MRE11 Are Involved in the Repair of Particulate Chromium (VI)-Induced DNA Double Strand Breaks. Toxicological Sciences 90: 544, 2006.

Savery, L.C., Wise, S.S., and Wise, Sr., J.P. Particulate Chromium Induced DNA-DNA Crosslinks Lead to Chromosome Damage. Toxicological Sciences 90: 545, 2006.

Wise, Sr., J.P. Sperm Whales: Are They Exposed to Dangerous Levels of Metals and Are They Sentinels for Human Health? A Case Study of the Toxic Effects of Chromium. Proceedings of the Consultative Group on Biological Diversity’s Annual Marine Working Group, March, 2006.

Wise, S.S., Kirstein, D., Romano, T., and Wise, Sr., J.P. The National Marine Cell Line Library. Proceedings of the annual meeting of the Northeast Regional Stranding Network, March, 2006.

Wise, S.S., Holmes, A., Xie, H., Mason, M.D., Chada, V.G.R., Goodale, B., Shaffiey, F., LaCerte, C., Qin, Q., Ng., A.K. and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Gold Nanospheres in Human Lung Cells. Presented at the workshop: Overcoming Obstacles to Effective Research Design in Nanotoxicology, April, 2006.

Wise, S.S., Pfefferle, L., Goodale, B., Bresler, A., Ng, A., and Wise, Sr., J.P. The Genotoxicity of Carbon Single-Walled Nanotubes in Human Bronchial Cells. Presented at the workshop: Overcoming Obstacles to Effective Research Depresesign in Nanotoxicology, April, 2006.

Knight, T., Wise, S.S., Wise, Sr., J.P., and Ng, A.K. Immunological and Toxic Effects of Gold Nanoparticles. Presented at the workshop: Overcoming Obstacles to Effective Research Design in Nanotoxicology, April, 2006.

Duzevik, E.G., Wise, S.S., Munroe, R.C., and Wise, Sr., J.P. XRCC1 Is Involved in Repair of Lead Chromate-Induced Chromosome Damage. Proceedings of the American Association for Cancer Research 47: 1072, 2006.

Karaczyn, A.A., Xie, H., and Wise, Sr., J.P. Depleted Uranium Induced Malignant Transformation in Human Lung Epithelial Cells. Proceedings of the American Association for Cancer Research 47: 5215, 2006.

Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C., and Wise, Sr., J.P. Lead Chromate-Induced Chromosome Instability is Caused by Centrosome Amplification in Human Lung Cells. Proceedings of the American Association for Cancer Research 47: 1088, 2006.

Xie, H, Wise, S.S., Deko, S., Katsifis, S., and Wise, Sr., J.P. Functional Role of MRE11 in the Repair of Particulate Chromium (VI)-Induced DNA Double Strand Breaks. Proceedings of the American Association for Cancer Research 47: 1086, 2006.

Savery, L.C., Wise, S.S., and Wise, Sr., J.P. Lead Chromate Induces DNA-DNA Crosslinks Leading to Chromosome Damage. Proceedings of the American Association for Cancer Research 47: 1084, 2006.

Wise, S.S., Stackpole, M.M., Camrye, E., Duzevik, E.G., and Wise, Sr., J.P. Particulate Chromate-Induced Chromosome Instability Is Attenuated by Non-Homologous End Joining and Homologous Recombination Repair. Proceedings of the American Association for Cancer Research 47: 1087, 2006.

Wise, S.S., Kelly, R.S., Throckmorton, H., Kraus, S., O’Hara, T., Romano, T., and Wise, Sr., J.P. The Effect of Environmental Contaminants: Chromium, Mercury and Tributyltin, on Northern Atlantic Right Whale Cells. Proceedings of the Annual Meeting of the International Association of Aquatic Animal Medicine, 37: 110, 2006.

Goodale, B.C., Wise, S.S., Walter, R.B., Ju, Z., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Hexavalent Chromium and Hypoxia in Medaka Cells. Proceedings of the North Atlantic Chapter of the Society or Environmental Toxicology and Chemistry, June, 2006.

Shaffiey, F., Wise, S.S., Kraus, S., O’Hara, T., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Cr(VI) in Lung and Testes Cells from the Northern Right Whale (Eubalaena glacialis). Proceedings of the North Atlantic Chapter of the Society or Environmental Toxicology and Chemistry, June, 2006.

Throckmorton, H., Wise, S.S., Kelly, R., Kraus, S., O’Hara, T., Romano, T., and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Mercury in Bowhead Whale (Balaena mysticetus) and Human Lung Cells. Proceedings of the North Atlantic Chapter of the Society of Environmental Toxicology and Chemistry, June, 2006.

Lacerte, C., Wise, S.S., Wise, Jr., J.P., Kerr, I.A.R., Payne, R., Evers, D., and Wise, Sr., J.P. Chromium Exposure and Its Toxicity in the Sperm Whale. Proceedings of the North Atlantic Chapter of the Society of Environmental Toxicology and Chemistry, June, 2006.

Bank, M.S., Crocker, J.B., Wachtl, J.L., Kleeman, P., Currens, C., Fellers, G., May, J., Hothem, R., Wise, J.P., Madej, M.A. Mercury Bioaccumulation in Pacific Giant Salamander Larvae from Lotic Ecosystems in the Pacific Northwestern United States. Presented at the Conference on Mercury as a Global Pollutant (Mercury 2006), Madison, Wisconsin, August, 2006

Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C., and Wise, Sr., J.P. Lead Chromate Induces Chromosome Instability via Centrosome Amplification and Spindle Assembly Checkpoint Bypass in Human Lung Cells. Fourth Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis. National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia, September, 2006.

Xie, H., Wise, S.S., Deko, S., Katsifis, S., and Wise, Sr., J.P. Impaired Repair of Lead Chromate-Induced DNA Double Stand Break Leads To Neoplastic Transformation. Fourth Conference on Molecular Mechanisms of Metal Toxicity and Carcinogenesis. National Institute for Occupational Safety and Health (NIOSH), Morgantown, West Virginia, September, 2006.

Savery, L.C., Grlickova-Duzevik, E., Wise, S.S., Thompson, W.D., Hinz, J.M., Thompson, L.H., and Wise, Sr., J.P. Fancg Gene Protects Cells from Particulate Chromate-Induced Chromosome Instability. Proceedings of the EpA Graduate Fellowship Conference, September, 2006.

Karaczyn, A.A., Xie, H, Cheng, R.Y.S., and Wise, Sr., J.P. In Vitro Toxicity and Neoplastic Transformation of Depleted Uranium: Effects on Human Bronchial Epithelial Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C., and Wise, Sr., J.P. Lead Chromate-Induced Chromosome Instability and Centrosome Amplification is Not Mediated by Lead. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Uygur, B., Wise, S.S., Mason, M.D., Ng, A.K., and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Silver Nanoparticles. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Goodale, B.C., Wise, S.S., Walter, R.B., Ju, Z., Winn, R.N., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Hexavalent Chromium in Medaka Cells and Interactions with Hypoxia. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Shaffiey, F., Wise, S.S., Kraus, S., O’Hara, T., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Cr(VI) in Lung and Testes Cells from the Northern Right Whale (Eubalaena glacialis). Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Xie, H., Wise, S.S., and Wise, Sr., J.P.  Functional Role of MRE11 in the Repair of Particulate Cr(VI)-induced DNA Double Strand Breaks. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Savery, L.C., Xie, H., Holmes, A.L., Wise, S.S., and Wise, Sr., J.P. Particulate Hexavalent Chromium Causes Chromosome Instability through Decreased Expression of Spindle Assembly Checkpoint Proteins. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Stackpole, M.M., Wise, S.S., Duzevik, E.G., Munroe R.C., Thompson, L.H., Thacker, J., and Wise, Sr., J.P. Homologous Recombination Repair Protects Against Chromate-induced Chromosome Instability in Chinese Hamster Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Qin, Q., Wise, S.S., Oberdorster, G., Mason, M.D., Xie, H., and Wise, Sr., J.P. The Cytotoxicity of Copper Nanoparticles in Human Lung Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Wise, S.S., Mason, M.D., Chada, V.G.R, LaCerte, C, Ng, A.K., and Wise, Sr., J.P. The Cytotoxicity of Gold Nanospheres in Human Lung Cells. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Huang, S., Xie, H., Peng, C., Gupta, B.C., and Wise, Sr., J.P. Particulate Chromate-Induced Gene Changes in Microarrays. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Li Chen, T., Wise, S.S., Kraus, S., O’Hara, T., and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Mercury and TBT in the Northern Atlantic Right Whale. Proceedings of the Northeast Society of Toxicology (NESOT) Annual Meeting, October 2006.

Goodale, B.C., Wise, S.S., Walter, R.B., Ju, Z., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Hexavalent Chromium and Hypoxia in Medaka Cells. Society of Environmental Chemistry and Toxicology (SETAC) Abstracts, p. 114, 2006.

Shaffiey, F., Wise, S.S., Kraus, S., O’Hara, T., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Cr(VI) in Lung and Testes Cells from the Northern Right Whale (Eubalaena glacialis). Society of Environmental Chemistry and Toxicology (SETAC) Abstracts, p. 316, 2006.

Wise, S.S., Lacerte, C., Wise, Jr., J.P., Kerr, I.A.R., Payne, R., Evers, D., and Wise, Sr., J.P. Chromium Exposure and Its Toxicity in the Sperm Whale. Society of Environmental Chemistry and Toxicology (SETAC) Abstracts, p. 316, 2006.

Li Chen, T., Wise, S.S., Kraus, S., O’Hara, T., and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Mercury and TBT in the Northern Atlantic Right Whale. Society of Environmental Chemistry and Toxicology (SETAC) Abstracts, p. 316, 2006.

Wise, S.S., Goertz, C.E.C, Morin, A.T., Dunn, J.L., Gulland, F.M.D., Bozza, M., Atkinson, S., Thompson, W.D., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Chromium in Steller Sea Lion Lung, Skin and Testes Cells. Society of Environmental Chemistry and Toxicology (SETAC) Abstracts, p. 316, 2006.

Bank, M.S., Crocker, J.B.  Wachtl, J. Kleeman, P., Currens, C., Fellers, G., May, J., Hothem, R., Wise, J., and  Madej, M.A.  2006.  Spatial Variation in Mercury Bioaccumulation, Energy Flow, and Trophic Complexity in Giant Salamanders from the Pacific Northwestern United States.  Society of Environmental Chemistry and Toxicology (SETAC) Abstracts, p. 345, 2006.

Wise, S.S., Throckmorton, H., Li Chen, T., Kraus, S., O’Hara, T., and Wise, Sr., J.P.  Cytotoxicity and Genotoxicity of Chromium and Mercury in Bowhead and North Atlantic Right Whale Cells. Proceedings of the Annual Meeting of the North Atlantic Right Whale Consortium, November. 2006.

Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C., and Wise, Sr., J.P. Centrosome Amplification is a Mechanism for Genomic Instability Induced by Environmental Carcinogens in Human Lung Cells. Proceedings of the Keystone Symposia on Genomic Instability and Repair, 161, 2007.

Wise, S.S., Holmes, A.L., Xie, H., Thompson, W.D., and Wise, Sr., J.P. Chemical Carcinogens Target the Centromere to Induce Chromosome Instability in Human Lung Cells. Proceedings of the Keystone Symposia on Genomic Instability and Repair, 344, 2007.

Xie, H., Wise, S.S., and Wise, Sr., J.P. MRE11 Protects Cells From DNA Double Strand Break-Induced Neoplastic Transformation. Proceedings of the Keystone Symposia on Genomic Instability and Repair, 346, 2007.

Savery, L.C., Xie, H., Holmes, A.L., Wise, S.S., and Wise, Sr., J.P. Particulate Hexavalent Chromium Induces Chromosome Instability and Decreased Expression of Spindle Assembly Checkpoint Proteins. Toxicological Sciences 96: 635, 2007.

Stackpole, M.M., Wise, S.S., Duzevik, E.G., Munroe R.C., Thompson, L.H., Thacker, J., and Wise, Sr., J.P.  Rad51D, XRCC3, and Rad51C Play a Role in Repairing Chromate-Induced Chromosome Instability in Mammalian Cells by Homologous Recombination. Toxicological Sciences 96: 1082, 2007.

Huang, S., Xie, H., Peng, C., Gupta, B.C., and Wise, Sr., J.P. Microarray Analysis of Particulate Chromate-Induced Gene Changes in Human Lung Cells. Toxicological Sciences 96: 1083, 2007.

Xie, H., Wise, S.S., and Wise, Sr., J.P. Impaired Repair of Particulate Cr(VI)-induced DNA Double Strand Breaks Leading to Neoplastic Transformation. Toxicological Sciences 96: 1084, 2007.

Wise, S.S., Shaffiey, F., Lacerte, C., Payne, R., Kerr, I.A.R., Kraus, S., and Wise, Sr., J.P. The Effects of Chromium on Human, Sperm Whale and North Atlantic Right Whale Cells. Proceedings of the Biennial Meeting of PRIMO (Pollution Research in Marine Organisms), May, 2007.
 
Li Chen, T., Wise, S.S., Kraus, S., O’Hara, T., Kerr, I.A.R., Payne, R., and Wise, Sr., J.P. Genotoxicity of Mercury in the North Atlantic Right Whale (Eubalaena glacialis) and in the Sperm Whale (Physeter macrocephalus). Proceedings of the Biennial Meeting of PRIMO (Pollution Research in Marine Organisms), May, 2007.

Wise, S.S., Mason, M.D., Shaffiey, F., Li Chen, T., Goodale, B., Craig, G., Walter, R., Payne, R., Kerr, I.A.R., Winn, R. and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Silver Nanoparticles in Target Species. Proceedings of the Biennial Meeting of PRIMO (Pollution Research in Marine Organisms), May, 2007.

Wise, S.S., Lacerte, C., Wise, Jr., J.P.,  Kerr, I.A.R., Payne, R., Evers, D., and Wise, Sr., J.P. The Effects of Chromium Exposure and Its Toxicity in the Sperm Whale. Proceedings of the Biennial Meeting of PRIMO (Pollution Research in Marine Organisms), May, 2007.

Holmes, A.L., Wise, S.S., Sandwick, S.J., Lingle, W.L., Negron, V.C., and Wise, Sr., J.P. Environmental Carcinogens Induce Chromosome Instability through Centrosome Amplification in Human Lung Cells. Proceedings of the 7th International Chromosome Segregation and Aneuploidy Workshop, T36, 2007.

Savery, L.C., Holmes, A.L., Sandwick, S.J., Xie, H., Wise, S.S., and Wise, Sr., J.P. Lead Chromate Induced Chromosome Instability and Decreased Expression of Key Spindle Assembly Checkpoint Proteins. Proceedings of the 7th International Chromosome Segregation and Aneuploidy Workshop, T33, 2007.

Wise, S.S., Mason M.D., Holmes, A.L., Savery, L., Li Chen, T., Goodale, B., Shaffiey, F., Wise, Jr, J.P., Craig, G., Walter, R., Payne, R., Kerr, I., Spaulding, M., and Wise, Sr., J.P. Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human and Marine Cell Lines. Environmental and Molecular Mutagenesis. 48(7): 606, 2007.

Wise, Sr., J.P., Wise, S.S., Kraus, S., Shaffiey, F., Grau, M., Li Chen, T., Perkins, C., Thompson, W.D., Zheng, T., Zhang, Y., Romano, T., and O’Hara, T. The Cytotoxic and Genotoxic of Hexavalent Chromium In North Atlantic Right Whale (Eubalaena glacialis) Cells. Proceedings of the Annual Meeting of the North Atlantic Right Whale Consortium, November. 2007.

Wise, S.S., Wise, Jr, J.P., Xie, H., Mason M.D., Craig, G., Payne, R., Kerr, I.A.R., and Wise, Sr., J.P. The Cytotoxicity and Genotoxicity of Silver Nanoparticles in Sperm Whale Cells. Society of Environmental Chemistry and Toxicology (SETAC) Abstracts, p. 295, 2007.