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Her research interests are focused on investigating the role of centrosome amplification in lead chromate-induced carcinogenesis
Li Chen T, Lacerte C, Wise SS, Holmes A, Martino J, Wise JP Jr, Thompson WD, Wise JP Sr. Comparative cytotoxicity and genotoxicity of particulate and soluble hexavalent chromium in human and sperm whale (Physeter macrocephalus) skin cells. Comparative Biochemistry and Physiology. Toxicology and Pharmacology, in press.
Holmes AL, Wise JP Sr. Mechanisms of metal-induced centrosome amplification. Biochemical Society Transactions 2010; 38:1678-90.
Wise JP Sr, Wise SS, Holmes AL, Lacerte C, Shaffiey F, Aboueissa AM. The cytotoxicity and genotoxicity of hexavalent chromium in Steller sea lion lung fibroblasts compared to human lung fibroblasts. Comparative Biochemistry and Physiology. Toxicology and Pharmacology 2010; 152:91-8.
Wise SS, Holmes AL, Qin Q, Xie H, Katsifis S, Thompson WD, Wise JP Sr. Comparative genotoxicity and cytotoxicity of four hexavalent chromium compounds in human bronchial cells. Chemical Research in Toxicology 2010; 23:365-72.
Holmes AL, Wise SS, Pelsue SC, Aboueissa A-M, Lingle W, Salisbury J, Gallagher J, Wise JP Sr. Chronic exposure to zinc chromate induces centrosome amplification and spindle assembly checkpoint bypass in human lung fibroblasts. Chemical Research in Toxicology 2010; 23:386-95.