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Research Cores
Developmental Toxicology Core
This core investigates the impact of environmental contaminants on cellular, molecular and biochemical mechanisms during development. The core includes studies that span in vitro work to human population studies. Specific research projects examine direct and indirect effects of metals on cell signaling, cell cycle, apoptosis cell differentiation and behavior of the organism. For example, three of the research projects consider the effect of chronic arsenic exposure during development and the effects it exerts on the brain, immune system and cognitive behavior.
Collaborating investigators in this core include members: Bilsky, Carlson-Lynch, Champlin, Currie, Davidoff, Gordon, Haddow, Hamilton, Hicks, Kim, Knight, Lynes, Markowski, Mayer, Meyer, Mokler, Murphy, Paulu, Pelsue, Prudente, Rice, Smith, Sommer, Tomassoni, Thompson, Tippy, Van Beneden and Wise.
Genetic Toxicology/Carcinogenesis Core
This core investigates how environmental toxicants cause cancer and damage DNA either as a part of their carcinogenic mechanism or as a developmental hazard. The core includes substantial work concerning lung-related cancers and toxicants so studies of lung health are also included in this core. The core includes studies that span in vitro work to human population studies. Studies include mechanisms of genomic instability in metal-induced carcinogenesis, radiation in breast cancer, genetic predisposition to hemochromatosis, and interactions of arsenic and smoking in tumorigenesis.
Collaborating investigators in this core include members: Anderson, Bennett, D’Orsie, Duboise, Dunham, Gordon, Haddow, Hamilton, Knight, Langley-Turnbaugh, Leopold, Mayer, McClain, Milligan, Most, Murphy, Ng, Palomaki, Paulu, Pelsue, Smith, Stickney, Thompson, Van Beneden, Verrille, Whittaker, and Wise.
Marine Toxicology Core
This core is developing to address an emerging national need to better understand interactions and impacts of the marine environment and human health. The core includes studies considering contaminant effects on sentinel species for human health such as harbor seals and marine birds, as well as direct effects on key endangered species such as right whales, eagles and loons. These studies identify likely sources of human exposure to arsenic, mercury, and chromium and also serve as comparative toxicology studies that determine novel molecular responses to contaminants in these divergent species.
Collaborating investigators in this core include members: Austin, Duboise, Evers, Gordon, Hicks, Macrae, Page, Sommer, Thompson, Whittaker, and Wise.
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