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Godard, Beaudoin-- Research a Work-Out

Christina Beaudoin, assistant professor of sports medicine, is interested in health and diet issues and especially the effects of diet and physical activity levels on bone density in adolescent and middle-aged women.

Her current research was prompted by a Harvard University study that showed a higher incidence of fractures in adolescent girls who drank more carbonated drinks and were more active than a control group. The study had limitations in that it was based on self-reported, retrospective data.

To build on that study, Beaudoin with Janet Whatley Blum, assistant professor of sports medicine and a nutritionist, conducted a study of 50 women aged 20 to 45 and found that those who consumed more carbonated drinks didn't show less bone density. She did see greater density in association with higher dairy consumption, but this was also associated with higher levels of body fat. This preliminary study, which was supported by a Faculty Senate award, will require follow-up studies to try to clarify causes and results.

In addition, Beaudoin would like to reproduce the Harvard study with 13 to 18 year old subjects. She'd like to add to the basic study design collection of data on the correlation of dietary choices with a subject's self-esteem level to see if eating patterns are affected by body image.

Besides her research efforts, Beaudoin is involved in a summer camp that combines instructional sport activities with drug and alcohol abuse prevention, health and nutrition education, and career and educational opportunities. A grant she was awarded by the National Youth Sports Corporation (NYSC) for $47,500 will support a five week, half-day sports camp that is open to Greater Portland youth, 10 to 16, from economically disadvantaged backgrounds. The program, which will be one of about 200 in the country supported by the NYSC, will run through July.

Godard Helping Ill, Elderly
In the Costello Sports Complex, a stream of senior citizens are measured, tested for strength and thrown off balance. But researcher Michael Godard's aim is not to torture the elderly but to help them.  

Godard, assistant professor of sports medicine, hopes his tests of senior citizens in USM's Human Performance Lab will yield more knowledge on the effects of aging and heart disease. His work may even indicate how to reverse decline in physical capability. 

Godard studies the impact of congestive heart failure on muscle tissue and the effects of activity or inactivity on protein structures in muscle fibers. He also studies the ability in older people to increase the balancing reflex.

In normally active people during their prime years, Godard explains, there is a mix of fast twitch and slow twitch muscle tissue. Fast twitch tissue allows people to move suddenly and quickly, as in a reflex action, while slow twitch muscle helps the body sustain activity since it tires less quickly. As people age and generally become less physically active, their bodies replace fast twitch tissue with slow twitch. As a result, older people tend to have slower reflexes and are less able to move quickly.

Heart patients, however, have the opposite pattern of muscle tissue. This seemingly surprising result is caused by the lower rate of oxygen reaching muscle tissue in heart patients. Because fast-twitch muscle tissue requires less oxygen, heart failure causes muscle tissue to convert to fast-twitch tissue. This tissue fatigues very quickly, so heart patients lose some of the functionality of their muscles. They become less able to engage in activities, especially physically demanding ones, for any length of time.

Godard tests whether muscle components can be reversed through activity level by comparing active and non-active heart patients.

He recruits his research subjects through a collaboration with Dr. Joseph Wight, a Portland cardiologist who screens heart patients to find candidates that fit Godard's criteria for the study. Dr. Mark Bouchard, another local doctor, recruits and screens subjects for control groups. The subjects in both the active and inactive heart patients, and similar control groups made up of non-heart patients, range in age from 45 to 75, with a mean age in the 60s. The heart patients have to be ambulatory and fairly functional to participate.

Godard determines the quality of the muscle by measuring the size of a subject's thigh muscle through a medical scan and then divides the size by the strength of the thigh muscle, determined by using a measurement of kicking strength. He uses a biopsy technique to draw a muscle sample from below the skin that is about half the size of a pinky nail and contains some 1000-1500 single muscles fibers.

Under a microscope, Godard can dissect out these single fibers and through a lab technique can determine whether the fibers contain slow-twitch or fast-twitch proteins, or both if the tissue is in transition.

A comparison of the active and inactive heart subjects with like control groups indicates that physical activity has a definite effect on muscle fiber make-up.  Godard hopes to complement this research with future longitudinal research that would study the impact of increasing activity levels in subjects.

Another research project Godard has underway tests the ability of the elderly to increase their capability to balance.  Over an eight week period, Godard's subjects, all of whom are over 70 years old, shift their weight to keep their balance as they stand on a tilting platform. The subjects are prompted to shift their weight by gazing at a computer screen that indicates when they've got the tabletop in balance by showing a dot that, through their movements on the platform, is guided into a box. Over time, the difficulty of balancing is increased.

As the subject responds to the visual stimuli, the computer assesses the coordination of his or her nervous system with the upper and lower leg muscles. Through repetition, Godard says, the neuromuscular pathways become more refined. Godard has found that all his subjects, participating three times a week over the eight weeks, had their ability to balance increase by at least 100 percent, and some as much as 250 percent. 

Godard's research is supported by USM's Bioscience Research Institute of Southern Maine funds. He uses BRISM lab equipment for biochemical analyses, and equipment purchased by the Sports Medicine program to measure physical performance.

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